RAF Typhoon FGR4s have conducted a mission with France's air force in a joint strike targeting an hidden munitions depot in Syria used by the IS group, according to the UK's MoD.
The location, pinpointed through reconnaissance, was assessed as housing weapons and explosive materials, the announcement noted, and was positioned in mountains just to the north of the ancient city of Palmyra in Syria's central region.
"Our aircraft utilized laser-guided Paveway IV weapons to hit a several approach shafts leading to the facility... early reports suggest the objective was successfully hit," the MoD said.
There was no evidence of any civilian casualties in the attack conducted Saturday night and every plane involved made a safe return, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
Daesh - also known as Daesh - established extremist governance over parts of both Syria and Iraq prior to its 2019 collapse.
"This operation demonstrates our UK leadership, and commitment to operate in unison with allied nations, to eradicate any resurgence of IS and their dangerous and violent ideologies in the Middle East," the British Defence Secretary the minister said.
British military aircraft have carried out overwatch operations over Syrian airspace to "forestall any attempted comeback" of Islamic State following its routing at the Baghuz confrontation in 2019, the MoD reported.
"I must thank the personnel of our armed forces participating in this operation for their skill and their bravery," Healey commented. "They were part of a great many British personnel stationed over Christmas and New Year. This mission, to take out dangerous terrorists who pose a risk to our security, highlights how our armed forces are ready to step up, throughout the year, ensuring Britain's security domestically and strong abroad."
In December, the United States armed forces carried out what it termed a "major assault" on Daesh sites in Syria, after an ambush resulted in the deaths of two American soldiers and a local interpreter in Palmyra.
The United Nations says Islamic State still boasts roughly 5-7 thousand militants in Syria and Iraq.